Dermatology Glossary

Subcorneal pustular dermatosis

Synonym:

Sneddon-Wilkinson disease

Subcorneal pustular dermatosis is a chronic relapsing dermatosis consisting of crops of flaccid pustules that rupture easily, leaving a crust.
Lesions tend to occur in groups, sometimes in a gyrate pattern.
Histologically, there is a subcorneal bulla containing neutrophils.
The eruption tends to favor flexural surfaces. The eruption may be asymptomatic, but is more often pruritic.

Treatment:

• The condition remits spontaneously, often after many years.
• Dapsone 50 to 150 mg po daily is usually effective therapy.

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